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Cystic Tum ors which might be m ucinous • M ucinous cystic neoplasm s • Intraductal papillary m ucinous neoplasm s M ucinous cystic neoplasm s • A lm ost alw ays arise in w om en • O ften come up in the physique or tail of the pancreas • Essentially by no means come up from or involve the pancreatic duct system • the epithelial lining is m ade up of colum nar m ucinous cells and the supporting strom a is cellular and has an “ovarian” strom al phenotype – H istologically seems like ovarian strom a – Expresses sim ilar m arkers (estrogen receptors, progesterone receptors) M ucinous cystic neoplasm s • these tum ors can be benign, borderline or m alignant – Benign: no epithelial dysplasia – Borderline: epithelial dysplasia – M alignant: invasive adenocarcinom a • these tum or have m alignant potential and if in any respect possible surgical resection is advised M ucinous cystic neoplasm s Severallarge cysts Tallcolumnarmucinousepith elium “ O varian”type stroma Intraductal papillary m ucinous cystic neoplasm • A rise m ore incessantly in m en • A rise m ore frequently within the head of pancreas • A rise from and contain the m ajor and m inor pancreatic ducts • the epithelial lining is com prised of m ucinous colum nar cells • Can be benign, borderline or m alignant – Thus have m alignant potential and must be resected Intraductal papillary m ucinous neoplasm Papillary projectionswith inadilated duct Dilated ductwith papillary projections Islet Cell Tum ors (Pancreatic Endocrine Tum ors or Pancreatic N euroendocrine Tum ors) N orm al pancreas Sm all groups of endocrine cells (Islets of Langerhans) w hich secrete horm ones such as insulin, glucagon and gastrin IsletsofL angerh ans Pancreatic N euroendocrine Tum ors • R are com pared to adenocarcinom a • Clinical presentation – M ay present w ith sym ptom s associated to elevated horm one secretion • H yperinsulinem ia causing hypoglycem ia • H ypergastrinem ia inflicting elevated gastric acid manufacturing and severe ulcers (Zollinger‐Ellison syndrom e) – M ay present as a non‐useful (non‐secreting) m ass • This is the m ost com m on Pancreatic endocrine tum or Pancreatic endocrine tum ors H istologic options/develop th patterns N ests R ibbons Solid Electronmicrograph ofapancreatic neuroendocrine tumorcellsh owing neurosecretory granules(arrows) the end Parting phrases from Dr mens health girl next door generic 10mg alfuzosin with visa.